Pow.Bio, a pioneer in continuous biomanufacturing, has successfully scaled its platform to 3,000 liters at ATV Technologies‘ facility in Compiègne, France. Bühler Group, a global provider of solutions for food, feed, and advanced materials, collaborated on this milestone. The project produced three times more protein than traditional fed-batch processes, marking a significant validation of Pow.Bio’s technology at larger scales.
This achievement highlights improvements in productivity and cost reduction. Pow.Bio’s advanced machine learning algorithms and model predictive control systems replaced manual guesswork. These technologies enabled real-time process adjustments, ensuring seamless operations despite unexpected challenges. ATV’s expertise played a crucial role in demonstrating that continuous fermentation can be reliably scaled up worldwide.
The results include a more than threefold increase in dairy protein productivity and a cost of goods sold (COGS) reduction of over 50%. Additionally, Pow.Bio’s CapEx-light approach allowed increased output from minimal investment, thanks to adaptation of ATV’s existing infrastructure. Bühler supported facility modifications and ensured equipment readiness for continuous operation. The smooth technology transfer accelerated trial initiation and execution.
Shannon Hall, CEO of Pow.Bio, expressed enthusiasm, stating, “Our platform delivers reliable results at bigger scales, with excellent economic viability.” She added that this partnership helps customers bring products to market faster. Karima Zitouni, General Manager at ATV Technologies, praised the collaboration, noting that combining continuous processing with smart ML optimization exceeded expectations.
Thierry Duvanel from Bühler emphasized that integrating predictive, data-driven fermentation into existing plants is a quick, practical way to improve yields and stability. With further scaling plans in progress, this milestone signifies a major step toward dependable, large-scale biomanufacturing. The partners’ success demonstrates the potential of combining advanced technology and industry collaboration to reshape bioproduction globally.
